After a member of the President's staff is murdered, Ellen urges Duncan to back out of the assassination plot, while other members of the President's staff take matters into their own hands. Meanwhile, after scouring Nina's medical records, Ellen finds someone who might be a viable bone marrow donor.
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A high-octane suspense drama that centers on Dr. Ellen Sanders, a premier surgeon thrust into a chilling political conspiracy when she and her family are held captive in their home by rogue FBI Agent Duncan Carlisle, a desperate man doing the wrong thing for the right reasons, who orders Dr. Sanders to assassinate the President when she operates on him.
It’s the day of the President’s surgery and the various plots are in motion. Just before the surgery begins, Ellen is cornered by the First Lady, who finally sees through Ellen’s lies about her husband’s condition and forces her to tell the truth about the assassination plot. Ellen spills the secrets Kincaid has been keeping from his wife and she agrees to help get the bone marrow out of the hospital. Blair’s squad of hired terrorists move into position after passing themselves off as Secret Service agents, and they launch their diversionary attack just after Ellen nicks an artery during surgery. Once Ellen is alone with the President and Logan, she gives Logan a sedative, extracts the bone marrow, and prevents the President from bleeding out on the operating table. Once the terrorist threat is subdued, Ellen takes the bone marrow to Nina, who accepts it and apologizes for everything Duncan did to her family. Meanwhile, Duncan schemes with Vanessa to outwit Blair and free his family. He corners Blair at gunpoint at a fundraising banquet and demands that Blair’s men release Nina and Sawyer. Once they’ve been released, Blair lashes out, forcing Duncan to shoot and kill him. Duncan then confronts Archer, who has captured the rest of the Sanders family and demands payment for his services. The two battle in a brutal fistfight with Archer coming out on top, but Kramer arrives just in time to save Duncan and kill Archer. Duncan then reunites with Nina and Sawyer briefly, saying goodbye before turning himself in to the police for his actions.
After Duncan discovers Sandrine's betrayal, he decides to use her to save Nina and Sawyer. Also, just before Ellen is to operate on the President, the First Lady confronts her and forces Ellen to tell the truth about the assassination plot.
Ellen reveals to Duncan that she will not kill the President but will help him get what he needs, as long as he gives her something in return. Meanwhile, Nina finds out about Duncan's plan and flees the hospital.
When Brian goes to the police to expose Duncan and his team, he decides against telling the truth after Burton shows up and shows him evidence of Ellen and Duncan getting close. Meanwhile, Duncan's trip to New York City puts a snag in the plans to take out the President.
Duncan locks the Sanders family in a room for the day while he and his team head to New York City to eliminate the sniper team targeting President Kincaid. Meanwhile, Duncan's mother-in-law tells Burton she wants to expose the President.
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