Kyle Barnes has had a series of misfortunes in his life; his mother would beat him as a child and he was accused of attacking his own daughter. After attending an exorcism in his native town, he is convinced his mother and his wife were possessed and he was not the source of them going bad. He therefore teams up with Reverend Anderson to try and save people that are possessed by demons while putting up with the residents of his town who think he's bad news and would deserve to be in jail.
Nella fittizia cittadina di Rome, nella Virginia Occidentale, Kyle Barnes, dopo una vita tormentata da possessioni demoniache che hanno afflitto lui e i suoi cari, cerca di trascorrere la sua vita alienandosi quanto più possibile dal resto della società. Dopo un incontro fortuito con il reverendo Anderson, un pastore evangelico che aveva tentato di aiutarlo da bambino, questi gli chiede aiuto per un esorcismo da compiere su un bambino con il quale apparentemente non ha legami. Tuttavia, scopre presto di essere direttamente coinvolto in tali nuove manifestazioni soprannaturali, accorgendosi nell'occasione di come il suo sangue abbia un effetto repellente nei confronti del demone. Insieme a Anderson, decide quindi di provare a comprendere cosa si nasconda dietro tali esternazioni demoniache e quale sia il suo ruolo.
Outcast centers on Kyle Barnes, who has been plagued by possession since he was a child. Now an adult, he embarks on a spiritual journey to find answers, but what he uncovers could mean the end of life on Earth as we know it.
In the season finale, Kyle reluctantly joins forces with a mysterious stranger in an attempt to end the possession threat once and for all, but fears the man may be hiding something. Megan struggles to escape her captors. Reverend Anderson shares an unexpected source of strength with his old friend, Chief Giles.
Kyle and Anderson face down Sidney – until an unexpected threat intervenes. Megan leaves the relative safety of the backwoods church, and danger quickly finds her. Tragedy strikes the Giles family. An unexpected stranger rivets Kyle's attention.
Kyle faces the mysteries behind his powers. Reverend Anderson finally confronts Sidney as Doctor Park's plans grow in scale. Megan makes an unlikely friend – one who will prove dangerous. Chief Giles tries to defend himself and his wife from the tide of the possessed in Rome.
Kyle attempts to get his family to safety as the town of Rome becomes increasingly overrun by the possessed. Anderson takes Megan under his wing, bringing her to find solace in an unlikely place. Chief Giles realizes his wife has been resorting to desperate measures.
Kyle's family and friends mourn the aftermath of a disaster – until a revelation from Reverend Anderson compels them to use Amber's unique powers. Allison rejoins her family in Rome.