What happens when hyperintelligent roommates Sheldon and Leonard meet Penny, a free-spirited beauty moving in next door, and realize they know next to nothing about life outside of the lab. Rounding out the crew are the smarmy Wolowitz, who thinks he's as sexy as he is brainy, and Koothrappali, who suffers from an inability to speak in the presence of a woman.
Bernadette and Wolowitz leave their kids for the first time; Penny and Leonard try to keep a secret; Sheldon and Amy stick together; and Koothrappali makes a new friend, as the gang travels together into an uncharted future.
Sheldon and Amy await big news.
Leonard is pleasantly surprised when Beverly comes to visit and she's genuinely kind to him, until he finds out the real reason she's there. Also, Denise and Stuart overstay their welcome at the Wolowitz house.
Kripke has proof that Dr. Pemberton plagiarized his thesis in college, and Sheldon and Amy aren't sure if they should turn him in or not. Also, Wolowitz is happily surprised to learn that Bernadette wasn't the only waitress at the Cheesecake Factory who had a crush on him back in the day.
Koothrappali is worried people won't take him seriously in his own field after publishing a paper that suggests he may have discovered alien life. Also, Leonard wants to be the principal investigator on a plasma physics study.
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