The Sperm Cell - Production, Maturation, Fertilization, Regeneration (2nd Ed)
by Christopher J. De Jonge, Christopher L. R. Barratt Cambridge University Press | July 2017 | ISBN-10: 1107126320 | 316 Pages | PDF | 22.7 mb https://www.amazon.com/Sperm-Cell-Production-Fertilization-Regeneration/dp/1107126320
This revised and updated second edition provides a comprehensive account of the human male gamete. Detailed overviews of human sperm production, maturation, and function - and how these processes affect and influence fertility, infertility, and assisted reproduction - are given. A wide range of new developments including proteomics, spermatogenesis, sperm-specific WW domain-binding proteins, Ca2+ signalling, DNA packaging, epididymis are explored, whilst a new chapter presents information gained from mouse genetics, highlighting how it informs male fertility research. The impact of environmental factors during pre-pubertal and pubertal stages of life is also investigated. Featuring engaging prose with chapters organized topographically, The Sperm Cell remains an essential resource for andrologists, clinical scientists, and laboratory personnel.
About the Authors Christopher De Jonge is Director of the Andrology Program at the University of Minnesota Medical Center and Adjunct Professor in the Department of Urology at the University of Minnesota.
Christopher L. R. Barratt is Professor of Reproductive Medicine at the School of Medicine, University of Dundee, Ninewells Hospital, Dundee.
CONTENTS List of Contributors page vii
Foreword by Ryuzo Yanagimachi x
Preface xiii
1 Spermatogenesis: Clinical and Experimental Considerations 1
2 Sperm Chromatin Stability and Susceptibility to Damage in Relation to Its Structure 21
3 Sperm Ultrastructure in Fertile Men and Male Sterility: Revisiting Teratozoospermia 36
4 Sperm RNA and Its Use as a Clinical Marker 59
5 Role of the Epididymis in Sperm Maturation 73
6 Seminal Plasma Plays Important Roles in Fertility 88
7 Physiological and Pathological Aspects of SpermMetabolism 109
8 Regulation of Sperm Behaviour: The Role(s) of [Ca2+]i Signalling 126
9 Proteomics of Capacitation 143
10 Current Concepts and Unresolved Questions in Human Sperm Cumulus and Zona Interaction 152
11 Sperm-SpeciicWW-Domain-Binding Proteins 157
12 Fundamental Role for Sperm Phospholipase C in Mammalian Fertilization 177
13 Male Infertility and Assisted Reproduction 193
14 The Genetic Basis ofMale Infertility 208
15 The Sperm Epigenome 230
16 Environmental Factors andMale Fertility 240
17 Susceptibility of the Testis to Lifestyle and Environmental Factors During the Life Course 260
18 Mouse Genetics – How Does It Inform Male Fertility Research? 280
Index 297
Colour plates are to be found between pages 178 and 179.
